Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products-Reference-Cited by-同舟云学术

Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products

Published:2020 Issue:5 Volume:37 Page:609-616
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Shen Leo¹²³⁴^ORCID,Pelletier Jerry¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biochemistry

2. McGill University

3. Montreal

4. Canada

5. Gerald Bronfman Department of Oncology

Abstract

This highlight reviews natural products targeting of the eIF4A RNA helicase by interfering with RNA-binding or acting as interfacial inhibitors to increase RNA resident time.

Funder

Canadian Institutes of Health Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NP/C9NP00052F

Reference55 articles.

1. From unwinding to clamping — the DEAD box RNA helicase family

2. The Organizing Principles of Eukaryotic Ribosome Recruitment

3. The mechanism of eukaryotic translation initiation and principles of its regulation

4. A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations

5. The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure

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