Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair

Author:

Musaie Kiyan1,Abbaszadeh Samin2,Nosrati-Siahmazgi Vahideh1,Qahremani Mostafa1,Wang Shige3,Eskandari Mohammad Reza4,Niknezhad Seyyed Vahid5,Haghi Fakhri6,Li Yulin7ORCID,Xiao Bo8ORCID,Shahbazi Mohammad-Ali1910ORCID

Affiliation:

1. Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Science, 45139-56184 Zanjan, Iran

2. Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, 45139-56111 Zanjan, Iran

3. School of Materials and Chemistry, the University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, P.R. China

4. Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Science, 45139-56184 Zanjan, Iran

5. Program in Craniofacial Biology, Department of Cell and Tissue Biology, University of California, San Francisco, CA 1, USA

6. Department of Microbiology and Immunology, Faculty of Medical Sciences, Zanjan University of Medical Sciences, 45139-56111 Zanjan, Iran

7. Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China

8. State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, 400715 China

9. Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands

10. W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

Abstract

Rapid metal coordination-based formation of a hydrogel is combined with the loading of photoactive nanoparticles and a regenerative drug to establish a multifunctional formulation for cancer therapy and mild-temperature wound healing acceleration.

Funder

Iran National Science Foundation

National Natural Science Foundation of China

Rijksuniversiteit Groningen

Zanjan University of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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