Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR – Ullmann cross-coupling sequence-Reference-Cited by-同舟云学术

Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR – Ullmann cross-coupling sequence

Published:2018 Issue:8 Volume:16 Page:1242-1246
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Van der Poorten O.¹²³⁴⁵,Van Den Hauwe R.¹²³⁴⁵,Hollanders K.¹²³⁴⁵^ORCID,Maes B. U. W.⁶⁷⁸⁹⁵^ORCID,Tourwé D.¹²³⁴⁵,Jida M.¹²³⁴⁵^ORCID,Ballet S.¹²³⁴⁵^ORCID

Affiliation:

1. Research Group of Organic Chemistry

2. Departments of Chemistry and Bioengineering Sciences

3. Vrije Universiteit Brussel

4. B-1000 Brussels

5. Belgium

6. Organic Synthesis

7. Department of Chemistry

8. University of Antwerp

9. 2020 Antwerp

Abstract

A 3-step methodology afforded the title compounds in moderate to good yields, with in silico and NMR conformational studies showing that the lowest energy conformers stabilize γ- and β-turn structures.

Funder

Fonds Wetenschappelijk Onderzoek

Agentschap Innoveren en Ondernemen

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB03094K

Reference25 articles.

1. 1,5-Benzothiazepine, a versatile pharmacophore: A review

2. Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target