The use of metabolomics in the study of metals in biological systems

Author:

Jones Oliver A. H.123,Dias Daniel A.4567,Callahan Damien L.891011,Kouremenos Konstantinos A.412613,Beale David J.141516,Roessner Ute4567

Affiliation:

1. School of Applied Sciences

2. RMIT University

3. Melbourne, Australia

4. Metabolomics Australia

5. School of Botany

6. The University of Melbourne

7. Parkville, Australia

8. Centre for Chemistry and Biotechnology

9. School of Life and Environmental Sciences

10. Deakin University

11. Melbourne VIC 3125, Australia

12. Bio21 Molecular Science and Biotechnology Institute

13. , Australia

14. Commonwealth Scientific and Industrial Research Organisation (CSIRO)

15. Land and Water

16. Highett, Australia

Abstract

Metabolomics and systems biology/toxicology can elucidate novel pathways and mechanistic networks of metals and metalloids in biological systems, as well as providing useful biomarkers of the metal status of organisms.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Reference84 articles.

1. J. J. R. F. Frausto da Silva , R. J. P.Williams , The Biological Chemistry of the Elements: The Inorganic Chemistry of Life , Oxford University Press , Oxford , 2001

2. T. J. Lyons and D. J.Eide , in Biological Inorganic Chemistry: Structure and Reactivity , ed. I. Bertini , H. Gray , E. Stiefel and J. S. Valentine , University Science Books , Mill Valley, California, USA , 1st edn, 2007 , ch. 5, pp. 57–77

3. Iron Homeostasis: Recently Identified Proteins Provide Insight into Novel Control Mechanisms

4. Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper

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