Preparation and evaluation of 99mTc-labeled porphyrin complexes prepared using PNP and HYNIC cores: studying the effects of core selection on pharmacokinetics and tumor uptake in a mouse model-Reference-Cited by-同舟云学术

Preparation and evaluation of 99mTc-labeled porphyrin complexes prepared using PNP and HYNIC cores: studying the effects of core selection on pharmacokinetics and tumor uptake in a mouse model

Published:2019 Issue:4 Volume:10 Page:606-615
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Guleria Mohini¹²³⁴,Das Tapas¹²³⁴⁵^ORCID,Vats Kusum¹²³⁴,Amirdhanayagam Jeyachitra¹²³⁴,Mathur Anupam⁶⁷⁸⁴,Sarma Haladhar D.⁹²³⁴,Dash Ashutosh¹²³⁴⁵

Affiliation:

1. Radiopharmaceuticals Division

2. Bhabha Atomic Research Centre

3. Mumbai - 400085

4. India

5. Homi Bhabha National Institute

6. Radiopharmaceuticals Program

7. Board of Radiation and Isotope Technology

8. Navi Mumbai - 400703

9. Radiation Biology and Health Sciences Division

Abstract

Demonstration of the effect of using two different ^99mTc-cores for radiolabeling of the same ligand: differential in vivo outcome.

Funder

Department of Atomic Energy, Government of India

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C8MD00559A

Reference35 articles.

1. Significantly increased lesion size by using the near-infrared photosensitizer 5,10,15,20-tetrakis (m-hydroxyphenyl)bacteriochlorin in interstitial photodynamic therapy of normal rat liver tissue

2. Biodistribution and Pharmacokinetic Studies of a Porphyrin Dimer Photosensitizer (Oxdime) by Fluorescence Imaging and Spectroscopy in Mice Bearing Xenograft Tumors

3. Glycosylated porphyrin derivatives and their photodynamic activity in cancer cells

4. An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy

5. Porphyrins as Theranostic Agents from Prehistoric to Modern Times

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