Chemo-enzymatic synthesis of chiral 3-substituted tetrahydroquinolines by a sequential biocatalytic cascade and Buchwald–Hartwig cyclization-Reference-Cited by-同舟云学术

Chemo-enzymatic synthesis of chiral 3-substituted tetrahydroquinolines by a sequential biocatalytic cascade and Buchwald–Hartwig cyclization

Published:2023 Issue:12 Volume:25 Page:4667-4673
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Xu Zefei¹^ORCID,Feng Jinhui¹^ORCID,Yao Peiyuan¹^ORCID,Wu Qiaqing¹^ORCID,Zhu Dunming¹^ORCID

Affiliation:

1. National Center of Technology Innovation for Synthetic Biology, National Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xi Qi Dao, Tianjin Airport Economic Area, Tianjin 300308, China

Abstract

A one-pot bienzymatic cascade was developed to synthesize (S)-N-(3-aryl-2-methylpropyl) prop-2-en-1-amines from α,β-unsaturated aldehydes, and 3-substituted tetrahydroquinolines were preparedviaBuchwald–Hartwig amination and deallylation.

Funder

National Key Research and Development Program of China

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/GC/D3GC00047H

Reference51 articles.

1. Advances in the Chemistry of Tetrahydroquinolines