Coenzyme Q10 attenuates platelet integrin αIIbβ3 signaling and platelet hyper-reactivity in ApoE-deficient mice-Reference-Cited by-同舟云学术

Coenzyme Q10 attenuates platelet integrin αIIbβ3 signaling and platelet hyper-reactivity in ApoE-deficient mice

Published:2020 Issue:1 Volume:11 Page:139-152
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Ya Fuli¹²³⁴⁵^ORCID,Xu Xiaohong Ruby⁶⁷⁸⁹¹⁰,Tian Zezhong¹¹¹²⁴⁵¹³^ORCID,Gallant Reid C.⁶⁷⁸⁹¹⁰,Song Fenglin¹⁴¹⁵⁴⁵^ORCID,Shi Yilin¹²³⁴⁵^ORCID,Wu Yinfan¹²³⁴⁵^ORCID,Wan Jianbo¹⁶¹⁷¹⁸¹⁹⁵^ORCID,Zhao Yimin¹¹¹²⁴⁵¹³^ORCID,Adili Reheman²⁰²¹²²²³,Ling Wenhua¹²³⁴⁵,Ni Heyu⁶⁷⁸⁹¹⁰^ORCID,Yang Yan¹¹¹²⁴⁵¹³^ORCID

Affiliation:

1. Department of Nutrition

2. School of Public Health

3. Sun Yat-sen University (Northern Campus)

4. Guangzhou

5. China

6. Department of Laboratory Medicine

7. Keenan Research Centre for Biomedical Science

8. St Michael's Hospital

9. Unity Health Toronto

10. Toronto

11. Guangdong Provincial Key Laboratory for Food

12. Nutrition and Health

13. Guangdong Province Engineering Laboratory for Nutrition Translation

14. School of Food Science

15. Guangdong Pharmaceutical University

16. State Key Laboratory of Quality Research in Chinese Medicine

17. Institute of Chinese Medical Sciences

18. University of Macau

19. Macau

20. Department of Pharmacology

21. University of Michigan

22. Ann Arbor

23. USA

Abstract

CoQ10 supplementation in ApoE^−/− mice attenuates high-fat diet-induced platelet hyper-reactivity via down-regulating platelet αIIbβ3 signaling, and thus protecting against atherothrombosis.

Funder

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Commission

Guangzhou Science, Technology and Innovation Commission

Canadian Institutes of Health Research

Heart and Stroke Foundation of Canada

Canada Foundation for Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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