Engineering of a Baeyer–Villiger monooxygenase reveals key residues for the asymmetric oxidation of omeprazole sulfide-Reference-Cited by-同舟云学术

Engineering of a Baeyer–Villiger monooxygenase reveals key residues for the asymmetric oxidation of omeprazole sulfide

Published:2022 Issue:95 Volume:58 Page:13246-13249
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wei Shiyu¹,Xu Guochao¹^ORCID,Zhang Lu¹,Zhou Jieyu¹,Ni Ye¹^ORCID

Affiliation:

1. Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China

Abstract

In the structure-guided engineering of RaBVMO for the sulfoxidation of bulky sulfides, mutant F442A/R337P exhibited ≥99% S-enantioselectivity toward omeprazole sulfide.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC04161H

Reference33 articles.

1. Titanium Catalyzed Enantioselective Oxidation of Thioethers with Hydrogen Peroxide

2. Asymmetric oxidation of sulfides

3. Baeyer–Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation

4. Chiral Sulfoxide Ligands in Asymmetric Catalysis

5. Unconventional Biocatalytic Approaches to the Synthesis of Chiral Sulfoxides

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