Pharmacokinetic profile and metabolite identification of bornyl caffeate and caffeic acid in rats by high performance liquid chromatography coupled with mass spectrometry-Reference-Cited by-同舟云学术

Pharmacokinetic profile and metabolite identification of bornyl caffeate and caffeic acid in rats by high performance liquid chromatography coupled with mass spectrometry

Published:2019 Issue:7 Volume:9 Page:4015-4027
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Shi Baimei¹²³⁴⁵,Yang Lingjian¹²³⁴⁵,Gao Tian¹²³⁴⁵,Ma Cuicui¹²³⁴⁵,Li Qiannan¹²³⁴⁵,Nan Yefei¹²³⁴⁵,Wang Shixiang¹²³⁴⁵,Xiao Chaoni¹²³⁴⁵,Jia Pu¹²³⁴⁵,Zheng Xiaohui¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Resource Biology and Biotechnology in Western China

2. Ministry of Education/College of Life Science

3. Northwest University

4. Xi'an 710069

5. P. R. China

Abstract

We revealed the metabolic profile of bornyl caffeate by HPLC-Q-TOF/MS, and then simultaneously examined the pharmacokinetics of bornyl caffeate and CA after administration of a single dose of bornyl caffeate by HPLC ion trap MS.

Funder

National Natural Science Foundation of China

Education Department of Shaanxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C8RA07972B

Reference42 articles.

1. Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

2. Caffeic Acid Phenethyl Ester Induces Leukocyte Apoptosis, Modulates Nuclear Factor-Kappa B and Suppresses Acute Inflammation

3. Anti-Inflammatory Activity of Phenyl Propanoids fromCoreopsis muticavar.mutica1

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