A non-immunosuppressive FK506 analogue with neuroregenerative activity produced from a genetically engineered Streptomyces strain-Reference-Cited by-同舟云学术

A non-immunosuppressive FK506 analogue with neuroregenerative activity produced from a genetically engineered Streptomyces strain

Published:2015 Issue:9 Volume:5 Page:6823-6828
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Shinde Pramod B.¹²³⁴⁵,Ban Yeon Hee¹²³⁴⁵,Hwang Jae-yeon¹²³⁴⁵,Cho Yumi⁶⁷⁸⁹⁵,Chen Yi-Ahn⁶⁷⁸⁹⁵,Cheong Eunji⁶⁷⁸⁹⁵,Nam Sang-Jip¹²³⁴⁵,Kwon Ho Jeong⁶⁷⁸⁹⁵,Yoon Yeo Joon¹²³⁴⁵

Affiliation:

1. Department of Chemistry and Nano Science

2. Ewha Global Top 5 Program

3. Ewha Womans University

4. Seoul 120-750

5. Republic of Korea

6. Department of Biotechnology

7. The Translational Research Center for Protein Function Control

8. Yonsei University

9. Seoul 120-746

Abstract

A new FK506 analogue, 9-deoxo-prolyl-FK506, was discovered and purified from the fkbD (responsible for C-9 oxidation) deletion mutant of Streptomyces sp. KCTC11604BP, and its biological activities were evaluated.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA11907J

Reference22 articles.

1. FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

2. FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

3. TACROLIMUS AND TRANSPLANTATION