Combining steady state and temperature jump IR spectroscopy to investigate the allosteric effects of ligand binding to dsDNA-Reference-Cited by-同舟云学术

Combining steady state and temperature jump IR spectroscopy to investigate the allosteric effects of ligand binding to dsDNA

Published:2021 Issue:28 Volume:23 Page:15352-15363
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Dale Jessica¹²³⁴,Howe C. Peter¹²³⁴^ORCID,Toncrova Hedvika⁵⁶⁷⁴,Fritzsch Robby⁸⁹¹⁰¹¹⁴,Greetham Gregory M.¹²¹³¹⁴¹⁵⁴,Clark Ian P.¹²¹³¹⁴¹⁵⁴,Towrie Michael¹²¹³¹⁴¹⁵⁴,Parker Anthony W.¹²¹³¹⁴¹⁵⁴^ORCID,McLeish Thomas C.⁸²³⁴^ORCID,Hunt Neil T.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and York Biomedical Research Institute

2. University of York

3. Heslington

4. UK

5. Department of Physics and Astronomy

6. University of Leeds

7. Leeds

8. Department of Physics

9. SUPA

10. University of Strathclyde

11. Glasgow

12. STFC Central Laser Facility

13. Research Complex at Harwell

14. Rutherford Appleton Laboratory

15. Didcot

Abstract

Changes in the structural dynamics of double stranded (ds)DNA upon ligand binding measured using T-jump spectroscopy are linked to the mechanism of allostery without conformational change.

Funder

Central Laser Facility, Science and Technology Facilities Council

University of Strathclyde

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP02233D

Reference43 articles.

1. Allostery without conformation change: modelling protein dynamics at multiple scales

2. Allostery without conformational change