Expansion of diazepine heterocyclic chemical space via sequential Knoevenagel condensation-intramolecular aza-Wittig reaction: 2-acyl-4-aryl-5H-pyrrolo[1,2-d][1,4]diazepines-Reference-Cited by-同舟云学术

Expansion of diazepine heterocyclic chemical space via sequential Knoevenagel condensation-intramolecular aza-Wittig reaction: 2-acyl-4-aryl-5H-pyrrolo[1,2-d][1,4]diazepines

Published:2020 Issue:48 Volume:18 Page:9836-9851
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Dagar Anuradha¹²³⁴,Kim Ikyon¹²³⁴^ORCID

Affiliation:

1. College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences

2. Yonsei University

3. Incheon

4. Republic of Korea

Abstract

Strategic combination of Knoevenagel condensation and intramolecular aza-Wittig reaction enabled facile access to pyrrole-fused 1,4-diazepines in excellent yields under mild conditions.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB02002H

Reference35 articles.

1. Privileged Diazepine Compounds and Their Emergence as Bromodomain Inhibitors

2. 1,4-Diazepines: A Review on Synthesis, Reactions and Biological Significance

3. Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists