Biological activity and structure–activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis-Reference-Cited by-同舟云学术

Biological activity and structure–activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis

Published:2023 Issue:7 Volume:14 Page:1344-1350
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Amaral Maiara¹²,Asiki Hannah³^ORCID,Sear Claire E.³,Singh Snigdha³,Pieper Pauline³,Haugland Marius M.³^ORCID,Anderson Edward A.³^ORCID,Tempone Andre G.²^ORCID

Affiliation:

1. Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo – 05403-000, Brazil

2. Centre for Parasitology and Mycology, Instituto Adolfo Lutz, São Paulo – 01246-000, Brazil

3. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK

Abstract

39 synthetic compounds based on the core scaffold of the neoligan dehydrodieugenol B presented activity against intracellular amastigotes of Leishmania.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Wellcome Trust

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

H2020 Marie Skłodowska-Curie Actions

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00081H

Reference20 articles.

1. Integrating Neglected Tropical Diseases into Global Health and Development: Fourth WHO Report on Neglected Tropical Diseases , World Health Organisation , 2017

2. Recent Advances in the Discovery of Novel Antiprotozoal Agents

3. Molecular targets and pathways for the treatment of visceral leishmaniasis

4. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

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