Pulmonary-arterial-hypertension (PAH)-on-a-chip: fabrication, validation and application-Reference-Cited by-同舟云学术

Pulmonary-arterial-hypertension (PAH)-on-a-chip: fabrication, validation and application

Published:2020 Issue:18 Volume:20 Page:3334-3345
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Al-Hilal Taslim A.¹²³⁴⁵,Keshavarz Ali¹²³⁴⁵,Kadry Hossam¹²³⁴⁵,Lahooti Behnaz¹²³⁴⁵,Al-Obaida Ahmed¹²³⁴⁵,Ding Zhenya⁶⁷⁸⁵,Li Wei⁶⁷⁸⁵^ORCID,Kamm Roger⁹¹⁰¹¹⁵¹²^ORCID,McMurtry Ivan F.¹³¹⁴¹⁵¹⁶⁵,Lahm Tim¹⁷¹⁸¹⁹²⁰⁵,Nozik-Grayck Eva²¹²²²³²⁴²⁵,Stenmark Kurt R.²¹²²²³²⁴²⁵,Ahsan Fakhrul¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences

2. Texas Tech University Health Sciences Center

3. Jerry H. Hodge School of Pharmacy

4. Amarillo

5. USA

6. Department of Chemical Engineering

7. Texas Tech University

8. Lubbock

9. Department of Mechanical Engineering

10. Massachusetts Institute of Technology

11. Cambridge

12. Department of Biological Engineering

13. Department of Pharmacology

14. The Center for Lung Biology

15. University of South Alabama

16. Mobile

17. Department of Pulmonary and Critical Care

18. Department of Medicine

19. Indiana University School of Medicine

20. Indianapolis

21. Department of Pediatrics and Medicine

22. Cardiovascular Pulmonary Research Laboratories

23. University of Colorado Denver

24. Anschutz Medical Campus

25. Aurora

Abstract

Current animal and cellular models only partially recapitulate the pathophysiology of PAH. Our PAH-on-a-chip model can mimic the major pathologies of PAH such as pulmonary arterial remodeling and sex disparity and help develop PAH therapeutics.

Funder

National Heart, Lung, and Blood Institute

Cardiovascular Medical Research and Education Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/D0LC00605J

Reference40 articles.

1. Molecular pathogenesis of pulmonary arterial hypertension

2. Pulmonary Arterial Hypertension: Challenges in Translational Research and a Vision for Change