Native mass spectrometric studies of IscSU reveal a concerted, sulfur-initiated mechanism of iron–sulfur cluster assembly-Reference-Cited by-同舟云学术

Native mass spectrometric studies of IscSU reveal a concerted, sulfur-initiated mechanism of iron–sulfur cluster assembly

Published:2023 Issue:1 Volume:14 Page:78-95
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Bennett Sophie P.¹,Crack Jason C.¹^ORCID,Puglisi Rita²^ORCID,Pastore Annalisa²^ORCID,Le Brun Nick E.¹^ORCID

Affiliation:

1. Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK

2. The Wohl Institute, King's College London, Denmark Hill Campus, London SE5 8AF, UK

Abstract

Time-resolved native mass spectrometry was used to investigate iron–sulfur cluster assembly on IscU. Data revealed a concerted assembly process in which sulfur (S0) transfer must occur first if IscU is in its Zn2+-bound form.

Funder

British Mass Spectrometry Society

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC04169C

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