Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions-Reference-Cited by-同舟云学术

Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions

Published:2022 Issue:4 Volume:13 Page:375-391
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Rudge Emma S.¹,Chan Alex H. Y.¹,Leeper Finian J.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

Abstract

Pyrophosphates (diphosphates) and bisphosphonates are potentially important drugs but are anionic and too polar to penetrate cells; here we review approaches that have been taken to create cell-permeable prodrugs of these type of compounds.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00297J

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