ESI MS studies highlight the selective interaction of Auranofin with protein free thiols-Reference-Cited by-同舟云学术

ESI MS studies highlight the selective interaction of Auranofin with protein free thiols

Published:2020 Issue:18 Volume:49 Page:5906-5913
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Zoppi Carlotta¹²³⁴⁵^ORCID,Messori Luigi¹²³⁴⁵^ORCID,Pratesi Alessandro⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Laboratory of Metals in Medicine (MetMed)

2. Department of Chemistry “Ugo Schiff”

3. University of Florence

4. Via della Lastruccia 3-13

5. 50019 Sesto Fiorentino

6. Department of Chemistry and Industrial Chemistry

7. University of Pisa

8. Via G. Moruzzi 13

9. 56124 Pisa

10. Italy

Abstract

The study of the mode-of-action of Auranofin, a cytotoxic gold(i) compound, reveals that it binds exclusively to the free and solvent-accessible cysteine residues of biologically relevant proteins.

Funder

Associazione Italiana per la Ricerca sul Cancro

Università di Pisa

Ente Cassa di Risparmio di Firenze

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT00283F

Reference60 articles.

1. Testicular cancer: A narrative review of the role of socioeconomic position from risk to survivorship

2. Review of the Comparative Pharmacology and Clinical Activity of Cisplatin and Carboplatin

3. Particular aspects of platinum compounds used at present in cancer treatment

4. Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells

5. Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: a comparative proteomic study

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