Nucleophile responsive charge-reversing polycations for pDNA transfection-Reference-Cited by-同舟云学术

Nucleophile responsive charge-reversing polycations for pDNA transfection

Published:2023 Issue:14 Volume:14 Page:1591-1601
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Lewis Reece W.¹^ORCID,Muralidharan Aswin¹²³^ORCID,Klemm Benjamin¹^ORCID,Boukany Pouyan E.¹,Eelkema Rienk¹^ORCID

Affiliation:

1. Department of Chemical Engineering, Delft University of Technology, 2629 HZ Delft, The Netherlands

2. Department of Bionanoscience, Delft University of Technology, 2629 HZ Delft, The Netherlands

3. Kavli Institute of Nanoscience, Delft University of Technology, 2629 HZ Delft, The Netherlands

Abstract

A new class of charge-reversing polycation is studied for transfection of mammalian cells. In a lipopolyplex formulation, we observed improved transfection and reduced toxicity compared to a permanently cationic control.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/PY/D3PY00075C

Reference45 articles.

1. Review on mechanistic strategy of gene therapy in the treatment of disease

2. Design concepts of polyplex micelles forin vivotherapeutic delivery of plasmid DNA and messenger RNA

3. Polymeric nano-carriers for on-demand delivery of genes via specific responses to stimuli

4. Polymeric Delivery of Therapeutic Nucleic Acids

5. Charge‐Conversion Strategies for Nucleic Acid Delivery

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