Conformational fingerprinting of tau variants and strains by Raman spectroscopy-Reference-Cited by-同舟云学术

Conformational fingerprinting of tau variants and strains by Raman spectroscopy

Published:2021 Issue:15 Volume:11 Page:8899-8915
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Devitt George¹²³⁴⁵^ORCID,Crisford Anna¹²³⁴⁵,Rice William⁶⁷³⁴⁵,Weismiller Hilary A.⁸⁹¹⁰¹¹,Fan Zhanyun¹²¹³¹⁴¹⁵¹⁶,Commins Caitlin¹²¹³¹⁴¹⁵¹⁶,Hyman Bradley T.¹²¹³¹⁴¹⁵¹⁶^ORCID,Margittai Martin⁸⁹¹⁰¹¹^ORCID,Mahajan Sumeet⁶⁷³⁴⁵^ORCID,Mudher Amrit¹²³⁴⁵^ORCID

Affiliation:

1. School of Biological Sciences

2. Faculty of Environmental and Life Sciences

3. University of Southampton

4. Southampton SO17 1BJ

5. UK

6. School of Chemistry

7. Faculty of Engineering and Physical Sciences

8. Department of Chemistry and Biochemistry

9. University of Denver

10. Denver

11. USA

12. Department of Neurology

13. Harvard Medical School

14. MassGeneral Institute for Neurodegenerative Disease

15. Massachusetts General Hospital

16. Charlestown

Abstract

We report that the physiochemical properties of the aggregation environment dictate the conformation of tau strains, which can be characterized and distinguished using Raman spectroscopy.

Funder

H2020 European Research Council

Engineering and Physical Sciences Research Council

National Institutes of Health

Rosetrees Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA00870F

Reference89 articles.