Myosin heavy chain-derived peptide of<i>Gadus morhua</i>promotes proliferation and differentiation in osteoblasts and bone formation and maintains bone homeostasis in ovariectomized mice-Reference-Cited by-同舟云学术

Myosin heavy chain-derived peptide ofGadus morhuapromotes proliferation and differentiation in osteoblasts and bone formation and maintains bone homeostasis in ovariectomized mice

Published:2023 Issue:11 Volume:14 Page:5151-5166
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yang Meilian¹,Cheng Shuzhen¹,Ma Wuchao¹,Wu Di¹,El-Seedi Hesham R.²^ORCID,Wang Zhenyu¹,Du Ming¹^ORCID

Affiliation:

1. School of Food Science and Technology, Collaborative Innovation Center of Seafood Deep Processing, National Engineering Research Center of Seafood, Dalian Polytechnic, University, Dalian 116034, China

2. Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, SE 751 24 Uppsala, Sweden

Abstract

A novel peptide (MNKKREAEFQ, P-GM-1) screened fromGadus morhuapeptides by molecular docking could promote bone formation and maintain bone homeostasis by activating the BMP-2 pathway, and is a potential anti-osteoporosis active ingredient.

Funder

Science and Technology Department of Liaoning Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO04083B

Reference48 articles.

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