An enantioselective aza-Friedel–Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines-Reference-Cited by-同舟云学术

An enantioselective aza-Friedel–Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines

Published:2021 Issue:17 Volume:19 Page:3820-3824
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liu Hui¹²³⁴⁵,Yan Yingkun¹²³⁴⁵,Li Min¹²³⁴⁵,Zhang Xiaomei¹²³⁴⁵^ORCID

Affiliation:

1. Asymmetric Synthesis and Chiraltechnology Key Laboratory of Sichuan Province

2. Chengdu Institute of Organic Chemistry

3. Chinese Academy of Sciences

4. Chengdu

5. China

Abstract

A chiral phosphoric acid catalyzed enantioselective aza-Friedel–Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines provided good yields and moderate to good enantioselectivities.

Funder

National Natural Science Foundation of China

Xihua University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00374G

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4. Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties

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