Barnase encapsulation into submicron porous CaCO3 particles: studies of loading and enzyme activity-Reference-Cited by-同舟云学术

Barnase encapsulation into submicron porous CaCO3 particles: studies of loading and enzyme activity

Published:2021 Issue:42 Volume:9 Page:8823-8831
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Yashchenok Alexey M.¹^ORCID,Gusliakova Olga I.²^ORCID,Konovalova Elena V.³^ORCID,Novoselova Marina V.¹^ORCID,Shipunova Victoria O.³^ORCID,Abakumova Tatiana O.⁴^ORCID,Efimova Olga I.⁵^ORCID,Kholodenko Roman³^ORCID,Schulga Alexey A.³^ORCID,Zatsepin Timofei S.⁴,Gorin Dmitry A.¹^ORCID,Deyev Sergey M.³^ORCID

Affiliation:

1. Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia

2. Remote Controlled Theranostic Systems Lab, Saratov State University, 410012 Saratov, Russia

3. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street 16/10, 117997 Moscow, Russia

4. Center for Life Science, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia

5. Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia

Abstract

The encapsulation efficiency of ribonuclease barnase in submicron CaCO3 particles can be enhanced by the use of anionic polyelectrolytes. The enzymatic activity of enzyme loaded particles is consistent with the loading capacity of these particles.

Funder

Russian Foundation for Basic Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2021/TB/D1TB01315G

Reference52 articles.

1. Barnase as a New Therapeutic Agent Triggering Apoptosis in Human Cancer Cells

2. Antitumor activity and toxicity of anti-HER2 immunoRNase scFv 4D5-dibarnase in mice bearing human breast cancer xenografts

3. Nanosized Delivery Systems for Therapeutic Proteins: Clinically Validated Technologies and Advanced Development Strategies