The causal association between artificial sweeteners and the risk of cancer: a Mendelian randomization study

Author:

Pan Haotian1ORCID,Feng Chenchen2,Zhou Ziting1,Huang Jiamin1,Deng Jiasi1,Zhou Yuanyuan1,Wang Yuxuan1,Mu Xinru1,Wang Qian3,Wang Ke2,Lu Zhigang456

Affiliation:

1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China

2. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

3. School of International Education, Nanjing University of Chinese Medicine, Nanjing 210023, China

4. School of Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China

5. Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, 210023, China

6. Jiangsu Collaborative Innovation Center ofTraditional Chinese Medicine in Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China

Abstract

Through the Mendelian randomization method, we found that artificial sweeteners (ASs) added to food had certain association with some types of cancers. Larger RCTs are needed to investigate small effects and support this conclusion.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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