Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition reactions of carboxylate-substituted enones-Reference-Cited by-同舟云学术

Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition reactions of carboxylate-substituted enones

Published:2017 Issue:29 Volume:15 Page:6089-6092
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yin Feng¹²³⁴,Garifullina Ainash¹²³⁴,Tanaka Fujie¹²³⁴^ORCID

Affiliation:

1. Chemistry and Chemical Bioengineering Unit

2. Okinawa Institute of Science and Technology Graduate University

3. Onna

4. Japan

Abstract

An enantioselective Michael addition reaction system was developed. Using the reaction system, 5-methylpyrrolidine-3-carboxylic acid was synthesized in two steps.

Funder

Ministry of Education, Culture, Sports, Science, and Technology

Japan Society for the Promotion of Science

Okinawa Institute of Science and Technology Graduate University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01484H

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3. Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2

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