Efficient construction of the hexacyclic ring core of palau'amine: the pKa concept for proceeding with unfavorable equilibrium reactions-Reference-Cited by-同舟云学术

Efficient construction of the hexacyclic ring core of palau'amine: the pKa concept for proceeding with unfavorable equilibrium reactions

Published:2021 Issue:36 Volume:12 Page:12201-12210
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ohashi Eisaku¹,Karanjit Sangita¹²,Nakayama Atsushi¹²^ORCID,Takeuchi Kohei¹,Emam Sherif E.¹^ORCID,Ando Hidenori¹,Ishida Tatsuhiro¹,Namba Kosuke¹²^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima, 770-8505, Japan

2. Research Cluster on “Innovative Chemical Sensing”, Tokushima University, 1-78 Shomachi, Tokushima, 770-8505, Japan

Abstract

A palau'amine analog (2) was synthesized from 2-cyclopentenone in 20 steps. The construction of the CDE tricyclic ring core in a single step is achieved by our pKa concept for proceeding with the unfavorable equilibrium reactions.

Funder

Japan Society for the Promotion of Science

Nagase Science Technology Foundation

Suntory Foundation

University of Tokushima

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC03260G

Reference65 articles.