Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2
Author:
Affiliation:
1. Department of Biochemistry
2. Charles University
3. Faculty of Science
4. 128 43 Prague 2
5. Czech Republic
6. Department of Chemistry and Biochemistry
7. Loyola University Chicago
8. Chicago
9. USA
Abstract
The structure and dynamics of the membrane-bound full-length human cytochrome P450 1A2 (CYP1A2) in aqueous solution determined by coarse-grained and all-atom molecular dynamics simulations.
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2016/CP/C6CP03692A
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4. Contributions of Human Enzymes in Carcinogen Metabolism
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