Fluid flow-induced modulation of viability and osteodifferentiation of periodontal ligament stem cell spheroids-on-chip

Author:

Mishra Apurva1ORCID,Kai Ren23ORCID,Atkuru Srividya1ORCID,Dai Yichen1ORCID,Piccinini Filippo45ORCID,Preshaw Philip M.6ORCID,Sriram Gopu17ORCID

Affiliation:

1. Faculty of Dentistry, National University of Singapore, Singapore

2. State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, Zhejiang, PR China

3. Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, Zhejiang, PR China

4. IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, Meldola, Italy

5. Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy

6. School of Dentistry, University of Dundee, Dundee, UK

7. NUS Centre for Additive Manufacturing (AM.NUS), National University of Singapore, Singapore

Abstract

Microfluidic spheroid-on-chip emulates physiologically relevant low fluid shear stress, resulting in improved PDLSC viability, enhanced osteodifferentiation, and uniform calcium deposition, offering new possibilities for periodontal research.

Funder

National University of Singapore

Ministry of Education - Singapore

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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