A phosphatase-like nanomaterial promotes autophagy and reprograms macrophages for cancer immunotherapy

Author:

Baimanov Didar1ORCID,Li Su23ORCID,Gao Xuejiao J.4ORCID,Cai Rui1,Liu Ke1,Li Junjie4,Liu Yuchen5,Cong Yalin16,Wang Xiaoyu7,Liu Fen8,Li Qi2,Zhang Guofang2,Wei Hui7ORCID,Wang Jian5,Chen Chunying16ORCID,Gao Xingfa9,Li Yang210ORCID,Wang Liming1ORCID

Affiliation:

1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Institute of High Energy Physics, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100049, P. R. China

2. Laboratory of Immunology and Nanomedicine & China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation, Laboratory of Inflammation and Vaccines, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China

3. Division of Allergy & Immunology, Department of Biosciences & Medical Biology, Paris Lodron University of Salzburg, 5020 Salzburg, Austria

4. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China

5. State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, P. R. China

6. New Cornerstone Science Laboratory, National Center for Nanoscience and Technology of China, Beijing 100049, P. R. China

7. College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing 210093, P. R. China

8. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P. R. China

9. Laboratory of Theoretical and Computational Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, P. R. China

10. The Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen, P. R. China

Abstract

Phosphatase-like nanozyme LNO specifically induces macrophage autophagy, improving antitumor immunity. Pre-coating LNO with myeloid cell membranes further enhances this effect, demonstrating significant therapeutic efficacy in vivo.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

National Key Research and Development Program of China

Chinese Academy of Sciences

Natural Science Foundation of Guangdong Province

Institute of High Energy Physics, Chinese Academy of Sciences

Natural Science Foundation of Beijing Municipality

Publisher

Royal Society of Chemistry (RSC)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3