Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors-Reference-Cited by-同舟云学术

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Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors

Published:2020 Issue:50 Volume:10 Page:29723-29736
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Hussein Abdel Haleem M.¹²³⁴⁵,Khames Ahmed A.¹²³⁴⁵,El-Adasy Abu-Bakr A.¹²³⁴⁵^ORCID,Atalla Ahmed A.¹²³⁴⁵,Abdel-Rady Mohamed¹²⁶⁷⁵,Hassan Mohamed I. A.⁸⁹¹⁰¹¹¹²,Nemr Mohamed T. M.¹³⁹¹⁴¹⁵⁵,Elshaier Yaseen A. A. M.¹⁶⁹¹⁷⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Faculty of Science

3. Al-Azhar University

4. Assiut 71524

5. Egypt

6. Assiut University

7. Assiut 71516

8. Department of Pharmacology & Toxicology

9. Faculty of Pharmacy

10. Al-Azhar University, Assiut Branch

11. Assiut

12. 71524 Egypt

13. Pharmaceutical Organic Chemistry Department

14. Cairo University

15. Cairo

16. Organic & Medicinal Chemistry Department

17. University of Sadat City

Abstract

A new series of 2-aminothiazole derivatives was designed and prepared as phosphodiesterase type 5 (PDE5) regulators and COX-1/COX-2 inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA05561A

Reference23 articles.

1. Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke

2. Sildenafil attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia

3. Acute Vardenafil Administration Improves Bladder Oxygenation in Spontaneously Hypertensive Rats

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