Novel camphor-based pyrimidine derivatives induced cancer cell death through a ROS-mediated mitochondrial apoptosis pathway-Reference-Cited by-同舟云学术

Novel camphor-based pyrimidine derivatives induced cancer cell death through a ROS-mediated mitochondrial apoptosis pathway

Published:2019 Issue:51 Volume:9 Page:29711-29720
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhang Yan¹²³⁴,Wang Yunyun¹²³⁴,Zhao Yuxun¹²³⁴,Gu Wen¹²³⁴⁵^ORCID,Zhu Yongqiang⁶³⁷,Wang Shifa¹²³⁴⁵^ORCID

Affiliation:

1. College of Chemical Engineering

2. Nanjing Forestry University

3. Nanjing

4. People's Republic of China

5. Co-Innovation Center of Efficient Processing and Utilization of Forest Resources

6. Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd

7. P. R. China

Abstract

A series of novel camphor-based pyrimidine derivatives were synthesized and characterized. We found the compound 3f exhibited strongest anti-tumor activity via ROS-mediated mitochondrial apoptosis pathway.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA05900H

Reference41 articles.

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