Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals

Author:

Adhikari Aniruddha12345ORCID,Das Monojit67895,Mondal Susmita12345,Darbar Soumendra1011125,Das Anjan Kumar1314155,Bhattacharya Siddhartha Sankar67895,Pal Debasish67895,Pal Samir Kumar12345ORCID

Affiliation:

1. Department of Chemical

2. Biological and Macromolecular Sciences

3. SN Bose National Centre for Basic Sciences

4. Kolkata-700106

5. India

6. Department of Zoology

7. Uluberia College

8. University of Calcutta

9. Uluberia

10. Research & Development Division

11. Dey's Medical Stores (Mfg.) Ltd

12. Kolkata-700019

13. Department of Pathology

14. Calcutta National Medical College and Hospital

15. Kolkata-700014

Abstract

Here, we have shown that citrate functionalized Mn3O4nanoparticles can ameliorate Mn-induced neurotoxicity (Parkinson's-like syndrome) through the chelation of excess Mn ions and subsequent reduction of oxidative damage.

Funder

Science and Engineering Research Board

Department of Biotechnology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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