Iron-mediated site-selective oxidative C–H/C–H cross-coupling of aryl radicals with quinones: synthesis of β-secretase-1 inhibitor B and related arylated quinones-Reference-Cited by-同舟云学术

Iron-mediated site-selective oxidative C–H/C–H cross-coupling of aryl radicals with quinones: synthesis of β-secretase-1 inhibitor B and related arylated quinones

Published:2019 Issue:18 Volume:6 Page:3244-3251
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

T.P Adarsh Krishna¹²³,Pandaram Sakthivel¹²³,Ilangovan Andivelu¹²³^ORCID

Affiliation:

1. Bharathidasan University

2. Tiruchirappalli

3. India

Abstract

Phenoxy radicals were converted intoparasite selectiveC-aryl radicals and coupled with quinones, using an inexpensive FeCl₃–K₂S₂O₈system, to obtain several arylated quinones, in good to moderate yields.

Funder

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C9QO00623K

Reference57 articles.

1. Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects

2. The chemical and biological activities of quinones: overview and implications in analytical detection

3. Quinone methide as a new intermediate in eumelanin biosynthesis.