Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells

Author:

Harizaj Aranit12345ORCID,Descamps Benedicte67345,Mangodt Christophe89345,Stremersch Stephan12345,Stoppa Arianna12345,Balcaen Lieve1011345,Brans Toon12345,De Rooster Hilde12133145ORCID,Devriendt Nausikaa12133145ORCID,Fraire Juan C.12345,Bolea-Fernandez Eduardo1011345ORCID,De Wever Olivier1516345,Willaert Wouter1716345,Vanhaecke Frank1011345ORCID,Stevens Christian V.89345ORCID,De Smedt Stefaan C.12345,Roman Bart89345ORCID,Vanhove Christian67345,Lentacker Ine12345,Braeckmans Kevin12345ORCID

Affiliation:

1. Laboratory of General Biochemistry and Physical Pharmacy

2. Faculty of Pharmaceutical Science

3. Ghent University

4. 9000 Ghent

5. Belgium

6. Infinity Lab

7. Faculty of Engineering and Architecture

8. Bioresources and Bioorganic Chemistry

9. Faculty of Bioscience Engineering

10. Atomic & Mass Spectrometry – A&MS Research Unit

11. Department of Chemistry

12. Small Animal Department

13. Faculty of Veterinary Medicine

14. 9820 Merelbeke

15. Laboratory Experimental Cancer Research

16. Faculty of Medicine and Health Science

17. Laboratory for Experimental Surgery

Abstract

Nanoparticle-sensitized photoporation for safe and efficient cytosolic delivery of gadolinium chelates, enabling high-contrast in vivo cell tracking of cells by magnetic resonance imaging.

Funder

Bijzonder Onderzoeksfonds UGent

Universiteit Gent

Fonds Wetenschappelijk Onderzoek

Agentschap Innoveren en Ondernemen

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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