A peptide-modified solid lipid nanoparticle formulation of paclitaxel modulates immunity and outperforms dacarbazine in a murine melanoma model

Author:

Banerjee Indranil12345ORCID,De Manjarika1234,Dey Goutam5674,Bharti Rashmi5674,Chattopadhyay Sankha89101112,Ali Nahid1234,Chakrabarti Partha131434,Reis Rui L.1516171819ORCID,Kundu Subhas C.1516171819,Mandal Mahitosh5674

Affiliation:

1. Division of Infectious Diseases and Immunology

2. Council of Scientific and Industrial Research–Indian Institute of Chemical Biology (CSIR-IICB)

3. Kolkata – 700032

4. India

5. School of Medical Science and Technology

6. Indian Institute of Technology Kharagpur

7. Kharagpur – 721302

8. Regional Centre

9. Radiopharmaceuticals Laboratory

10. Board of Radiation and Isotope Technology

11. Variable Energy Cyclotron Centre

12. Kolkata – 700064

13. Division of Cell Biology and Physiology

14. CSIR-IICB

15. 3Bs Research Group

16. I3Bs – Research Institute on Biomaterials

17. Biodegradables and Biomimetics

18. University of Minho

19. Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine

Abstract

Somatostatin receptor (SSTR) analog modified nanoparticles of paclitaxel (PSM) showed a superior anti-melanoma effect by inducing a favorable systemic immune response.

Funder

Science and Engineering Research Board

Board of Research in Nuclear Sciences

Council of Scientific and Industrial Research

Horizon 2020

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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