Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production-Reference-Cited by-同舟云学术

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

Author:

Cheignon Clémence¹²³⁴⁵,Faller Peter¹²³⁴⁵,Testemale Denis⁶⁷⁸⁹⁷,Hureau Christelle¹²³⁴⁵,Collin Fabrice¹²³⁴⁵

Affiliation:

1. LCC (Laboratoire de Chimie de Coordination)

2. CNRS UPR 8241

3. 31062 Toulouse Cedex 09, France

4. Université de Toulouse

5. UPS

6. University of Grenoble Alpes

7. Institut NEEL

8. F-38000 Grenoble, France

9. CNRS

Abstract

Aβ oxidation due to HO˙ production by Cu–Aβ/ascorbate changes copper coordination and leads to the self-enhancement of HO˙ production and release.

Funder

Agence Nationale de la Recherche

European Research Council

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

Reference48 articles.

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