Glycosaminoglycan from Apostichopus japonicus inhibits hepatic glucose production via activating Akt/FoxO1 and inhibiting PKA/CREB signaling pathways in insulin resistant hepatocytes-Reference-Cited by-同舟云学术

Glycosaminoglycan from Apostichopus japonicus inhibits hepatic glucose production via activating Akt/FoxO1 and inhibiting PKA/CREB signaling pathways in insulin resistant hepatocytes

Published:2019 Issue:11 Volume:10 Page:7565-7575
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Chen Yunmei¹²³⁴⁵,Liu Huimin⁶⁷⁸⁹^ORCID,Wang Yuanhong¹²³⁴⁵,Yang Shuang¹²³⁴⁵,Yu Mingming¹²³⁴⁵,Jiang Tingfu¹²³⁴⁵,Lv Zhihua¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs

2. Ministry of Education of China

3. Key Laboratory of Glycoscience & Glycotechnology of Shandong Province

4. School of Medicine and Pharmacy

5. Ocean University of China

6. College of Life Science

7. Jilin Agricultural University

8. Changchun

9. China

Abstract

AHG-induced activation of the Akt/FoxO1 signaling pathway and inhibition of the PKA/CREB signaling pathway regulated the expression of gluconeogenesis rate-limiting enzymes G6Pase and PEPCK, thus inhibiting HGP in insulin resistant hepatocytes.

Funder

National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/FO/C9FO01444F

Reference53 articles.