Solvent-controlled regioselective C(5)–H/N(1)–H bond alkylations of indolines and C(6)–H bond alkylations of 1,2,3,4-tetrahydroquinolines with <i>para</i>-quinone methides-Reference-Cited by-同舟云学术

Solvent-controlled regioselective C(5)–H/N(1)–H bond alkylations of indolines and C(6)–H bond alkylations of 1,2,3,4-tetrahydroquinolines with para-quinone methides

Published:2022 Issue:17 Volume:20 Page:3570-3588
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Akyildiz Volkan¹^ORCID,Lafzi Ferruh¹^ORCID,Kilic Haydar¹^ORCID,Saracoglu Nurullah¹^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, 25240, Turkey

Abstract

Solvent-switched regioselective N-alkylations (in HFIP : DCM) and C5-alkylations (in HFIP) of indolines using a broad range of p-QMs have been developed. The protocol successfully worked for the C6-alkylations of 1,2,3,4-tetrahydroquinolines.

Funder

Atatürk Üniversitesi

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00035K

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