Label-free target identification using in-gel fluorescence difference via thermal stability shift
Author:
Affiliation:
1. Department of Biophysics and Chemical Biology
2. Seoul National University
3. Seoul – 08826
4. Korea
5. CRI Center for Chemical Proteomics
6. Department of Chemistry
Abstract
A label-free method for proteome-wide target identification was developed using in-gel fluorescence difference caused by thermal stability shift.
Funder
National Research Foundation of Korea
Ministry of Science, ICT and Future Planning
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03238A
Reference32 articles.
1. Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack
2. Target identification of natural products and bioactive compounds using affinity-based probes
3. Phenotypic screening in cancer drug discovery — past, present and future
4. Target identification and mechanism of action in chemical biology and drug discovery
5. Determining target engagement in living systems
Cited by 31 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. CETSA and thermal proteome profiling strategies for target identification and drug discovery of natural products;Phytomedicine;2023-07
2. SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination;Communications Biology;2023-03-21
3. Native DIGE for Quantitative and Functional Analysis of Protein Interactomes;Methods in Molecular Biology;2022-11-16
4. Label-Free Target Identification Reveals the Anticancer Mechanism of a Rhenium Isonitrile Complex;Frontiers in Chemistry;2022-03-14
5. Precipitate-Supported Thermal Proteome Profiling Coupled with Deep Learning for Comprehensive Screening of Drug Target Proteins;ACS Chemical Biology;2022-01-06
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3