Effect of overexpression of endogenous and exogenous Streptomyces antibiotic regulatory proteins on tacrolimus (FK506) production in Streptomyces sp. KCCM11116P-Reference-Cited by-同舟云学术

Effect of overexpression of endogenous and exogenous Streptomyces antibiotic regulatory proteins on tacrolimus (FK506) production in Streptomyces sp. KCCM11116P

Published:2015 Issue:21 Volume:5 Page:15756-15762
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chen Chao¹²³⁴,Zhao Xinqing¹²³⁴¹,Chen Liangyu¹²³⁴,Jin Yingyu⁵⁶⁷⁸,Zhao Zongbao K.⁹¹⁰¹¹¹²⁴,Suh Joo-Won⁵⁶⁷⁸

Affiliation:

1. School of Life Science and Biotechnology

2. Dalian University of Technology

3. Dalian 116024

4. China

5. Division of Bioscience and Bioinformatics

6. Myongji University

7. Yongin 449-728

8. South Korea

9. Department of Biotechnology

10. Dalian Institute of Chemical Physics

11. Chinese Academy of Sciences

12. Dalian 116023

Abstract

Overexpression of SARPs enhanced FK506 production in Streptomyces sp. KCCM1116P. The endogenous SARPs improved production titer, whereas the exogenous SARP enhanced productivity at the early fermentation stage.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA15038D

Reference37 articles.

1. FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

2. FK-506?A Novel Immunosuppressant

3. Clinical trial of tacrolimus versus cyclosporine in lung transplantation

4. Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506)

5. Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transcriptional regulators of secondary metabolite biosynthesis in Streptomyces;World Journal of Microbiology and Biotechnology;2024-04-08

2. A new peucemycin derivative and impacts of peuR and bldA on peucemycin biosynthesis in Streptomyces peucetius;Applied Microbiology and Biotechnology;2024-01-12

3. Increasing Demeclocycline Production in Streptomyces aureofaciens by Manipulating the Expression of a Novel SARP Family Regulator and Its Genes;Biotechnology and Bioprocess Engineering;2021-12

4. Characterization and engineering of Streptomyces griseofuscus DSM 40191 as a potential host for heterologous expression of biosynthetic gene clusters;Scientific Reports;2021-09-15

5. Characterization and Engineering ofStreptomyces griseofuscusDSM 40191 as a Potential Host for Heterologous Expression of Biosynthetic Gene Clusters;2020-11-10