Computational analysis of hot spots and binding mechanism in the PD-1/PD-L1 interaction
Author:
Affiliation:
1. State Key Laboratory for Precision Spectroscopy
2. Shanghai Engineering Research Center of Molecular Therapeutics & New Drug Development
3. School of Chemistry and Molecular Engineering
4. East China Normal University
5. Shanghai 200062
Abstract
The hot spots quantitatively predicted by the recently developed MM/GBSA/IE method reveal a hydrophobic core in the PD-1/PD-L1 interaction.
Funder
Department of S and T for Social Development
E-Institutes of Shanghai Municipal Education Commission
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA01369E
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