Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-13C]glycine and its deuteration toward longer retention of the hyperpolarized state-Reference-Cited by-同舟云学术

Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-13C]glycine and its deuteration toward longer retention of the hyperpolarized state

Published:2021 Issue:59 Volume:11 Page:37011-37018
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kondo Yohei¹^ORCID,Saito Yutaro¹^ORCID,Elhelaly Abdelazim Elsayed²,Hyodo Fuminori²,Nishihara Tatsuya¹,Itoda Marino¹,Nonaka Hiroshi¹^ORCID,Matsuo Masayuki³,Sando Shinsuke¹⁴^ORCID

Affiliation:

1. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

2. Department of Radiology, Frontier Science for Imaging, School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan

3. Department of Radiology, School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan

4. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

Abstract

By examining enzymatic and magnetic properties, γ-Glu-[1-13C]Gly-d2 was developed as a long-lived DNP molecular probe for detecting γ-glutamyl transpeptidase.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA07343E

Reference30 articles.

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2. Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions

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4. A fluorine-18 labeled radiotracer for PET imaging of γ-glutamyltranspeptidase in living subjects

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