Type I photosensitizers based on phosphindole oxide for photodynamic therapy: apoptosis and autophagy induced by endoplasmic reticulum stress

Author:

Zhuang Zeyan1,Dai Jun2ORCID,Yu Maoxing1,Li Jianqing1,Shen Pingchuan1,Hu Rong1,Lou Xiaoding3ORCID,Zhao Zujin1ORCID,Tang Ben Zhong14ORCID

Affiliation:

1. State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China

2. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China

3. Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China

4. Department of Chemistry, The Hong Kong University of Science & Technology, Kowloon, Hong Kong, China

Abstract

Phosphindole oxide-based photosensitizers with Type I reactive oxygen species generation ability are developed and used for endoplasmic reticulum stress-mediated photodynamic therapy of tumors.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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