Double asymmetric synthesis: faster reactions are more selective and a model to estimate relative rate-Reference-Cited by-同舟云学术

Double asymmetric synthesis: faster reactions are more selective and a model to estimate relative rate

Published:2023 Issue:35 Volume:21 Page:7115-7128
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Richards Christopher J.¹^ORCID,Stephen Ojo O.¹

Affiliation:

1. School of Chemistry, University of East Anglia, Norwich, NR4 7TJ, UK

Abstract

Kinetic resolutions resulting in a new stereogenic centre were used to establish that in double asymmetric synthesis the faster reaction is more selective. The relative rate is estimated by a model using substrate (x) and catalyst (y) selectivities.

Funder

Leverhulme Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01048A

Reference57 articles.

1. Double Asymmetric Synthesis and a New Strategy for Stereochemical Control in Organic Synthesis

2. Multiple stereoselectivity and its application in organic synthesis

3. Role of Pseudoephedrine as Chiral Auxiliary in the “Acetate-Type” Aldol Reaction with Chiral Aldehydes; Asymmetric Synthesis of Highly Functionalized Chiral Building Blocks

4. Synthesis of chiral β2-amino acids by asymmetric hydrogenation

5. Enantioselective Synthesis of anti- and syn-Homopropargyl Alcohols via Chiral Brønsted Acid Catalyzed Asymmetric Allenylboration Reactions

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