Asymmetric difluoroalkylation <i>via</i> Michael addition of an <i>in situ</i> generated difluoroenol intermediate-Reference-Cited by-同舟云学术

Asymmetric difluoroalkylation via Michael addition of an in situ generated difluoroenol intermediate

Published:2024 Issue:17 Volume:11 Page:4702-4707
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xie Xiongda¹,Chen Gang¹,Huang Jingjing²,Liu Yongqiang³,Xu Xinfang¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China

2. School of Chemistry, Sun Yat-sen University, Guangzhou, Guangdong 510006, China

3. Research Center of Chinese Herbal Resource Science and Engineering, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510120, China

Abstract

An asymmetric difluoroalkylation using α,α-difluoroenol as the key synthon has been disclosed, providing oxindoles containing a chiral quaternary carbon center in generally good yields and with excellent stereoselectivities.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00987H

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