Gram-scale enzymatic synthesis of 2′-deoxyribonucleoside analogues using nucleoside transglycosylase-2-Reference-Cited by-同舟云学术

Gram-scale enzymatic synthesis of 2′-deoxyribonucleoside analogues using nucleoside transglycosylase-2

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Salihovic Admir¹²^ORCID,Ascham Alex³^ORCID,Taladriz-Sender Andrea¹²^ORCID,Bryson Samantha¹²,Withers Jamie M.¹²,McKean Iain J. W.¹²,Hoskisson Paul A.⁴^ORCID,Grogan Gideon³^ORCID,Burley Glenn A.¹²^ORCID

Affiliation:

1. Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, UK G1 1XL

2. Strathclyde Centre for Molecular Bioscience, University of Strathclyde, UK

3. Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK

4. Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK

Abstract

This work details the scope and scalability of biocatalytic nucleoside synthesis by the type II nucleoside 2′-deoxyribosyltransferase (LlNDT2).

Funder

Royal Academy of Engineering

Leverhulme Trust

University of Strathclyde

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC04938A

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