Design, synthesis and antiproliferative evaluation of tetrahydro-β-carboline histone deacetylase inhibitors bearing an aliphatic chain linker-Reference-Cited by-同舟云学术

Design, synthesis and antiproliferative evaluation of tetrahydro-β-carboline histone deacetylase inhibitors bearing an aliphatic chain linker

Author:

Shi Jing¹²,Wang Jiayun³,Wang Xingjie⁴,Qu Chao⁴^ORCID,Ye Changchun⁴,Li Xiuli²,Chen Xin³^ORCID,Xu Zhengshui¹^ORCID

Affiliation:

1. Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China

2. Department of Respiratory and Endocrinology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China

3. Shaanxi Key Labotory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China

4. Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China

Abstract

The use of histone deacetylase inhibitors (HDACis) is an effective approach for cancer treatment.

Funder

National Natural Science Foundation of China

Xi'an Jiaotong University

Natural Science Basic Research Program of Shaanxi Province

Key Research and Development Projects of Shaanxi Province

Publisher

Royal Society of Chemistry (RSC)

Link

Reference27 articles.