Helical structure in cyclic peptides: effect of N-methyl amides versus esters

Author:

Wu Chongyang1,Hoang Huy N.1ORCID,Hill Timothy A.1ORCID,Lim Junxian1ORCID,Kok W. Mei1,Akondi Kalyani1,Liu Ligong1ORCID,Fairlie David P.1ORCID

Affiliation:

1. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, University of Queensland, Brisbane, Qld 4072, Australia

Abstract

Cyclic peptides with esters but not N-methyl amides are the smallest known alpha helices in water and can enter cells.

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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