Evolutionary dynamics of natural product biosynthesis in bacteria-Reference-Cited by-同舟云学术

Evolutionary dynamics of natural product biosynthesis in bacteria

Published:2020 Issue:4 Volume:37 Page:566-599
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Chevrette Marc G.¹²³⁴⁵^ORCID,Gutiérrez-García Karina⁶⁷⁸⁹¹⁰,Selem-Mojica Nelly⁶⁷⁸⁹¹⁰^ORCID,Aguilar-Martínez César⁶⁷⁸⁹¹⁰,Yañez-Olvera Alan⁶⁷⁸⁹¹⁰,Ramos-Aboites Hilda E.⁶⁷⁸⁹¹⁰,Hoskisson Paul A.¹¹¹²¹³¹⁴^ORCID,Barona-Gómez Francisco⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Wisconsin Institute for Discovery

2. Department of Plant Pathology

3. University of Wisconsin-Madison

4. Madison

5. USA

6. Evolution of Metabolic Diversity Laboratory

7. Unidad de Genómica Avanzada (Langebio)

8. Cinvestav-IPN

9. Guanajuato

10. Mexico

11. Institute of Pharmacy and Biomedical Sciences

12. University of Strathclyde

13. Glasgow

14. UK

Abstract

We review known evolutionary mechanisms underlying the overwhelming chemical diversity of bacterial natural products biosynthesis, focusing on enzyme promiscuity and the evolution of enzymatic domains that enable metabolic traits.

Funder

Consejo Nacional de Ciencia y Tecnología

Biotechnology and Biological Sciences Research Council

Natural Environment Research Council

Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional

Royal Society

Microbiology Society

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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