Design, synthesis, anticancer activity and molecular docking studies of new benzimidazole derivatives bearing 1,3,4-oxadiazole moieties as potential thymidylate synthase inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, anticancer activity and molecular docking studies of new benzimidazole derivatives bearing 1,3,4-oxadiazole moieties as potential thymidylate synthase inhibitors

Published:2022 Issue:31 Volume:46 Page:14967-14978
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Almalki Abdulraheem SA¹,Nazreen Syed²^ORCID,Elbehairi Serag Eldin I.³⁴,Asad Mohammad⁵⁶,Shati Ali A.³,Alfaifi Mohammad Y.³,Alhadhrami Abdulrahman¹^ORCID,Elhenawy Ahmed A.²⁷^ORCID,Alorabi Ali Q.²,Asiri Abdullah M.⁵⁶^ORCID,Alam Mohammad Mahboob²

Affiliation:

1. Department of Chemistry, Faculty of Science, Taif University, Taif, Kingdom of Saudi Arabia

2. Department of Chemistry, Faculty of Science, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia

3. Department of Biology, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia

4. Cell Culture Laboratory, Egyptian Organization for Biological Products and Vaccines, VACSERA Holding Company, Giza 2311, Egypt

5. Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

6. Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

7. Chemistry Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt

Abstract

Compounds 10 and 14 arrest the cell cycle at the G1 phase and induce apoptosis without any necrosis in MDA-MB-231 cells.

Funder

Taif University

King Khalid University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ01980A

Reference48 articles.

1. 5-Fluorouracil: mechanisms of action and clinical strategies

2. Effect of the Thymidylate Synthase Inhibitors on dUTP and TTP Pool Levels and the Activities of DNA Repair Glycosylases on Uracil and 5-Fluorouracil in DNA

3. Targeting nuclear thymidylate biosynthesis

4. Thymidylate Synthase Structure, Function and Implication in Drug Discovery

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