Novel phenylthiazoles with a tert-butyl moiety: promising antimicrobial activity against multidrug-resistant pathogens with enhanced ADME properties

Author:

Hagras Mohamed1ORCID,Abuelkhir Abdelrahman A.1,Abutaleb Nader S.23,Helal Ahmed M.1,Fawzy Iten M.4ORCID,Hegazy Maghawry5ORCID,Seleem Mohamed N.26,Mayhoub Abdelrahman S.17

Affiliation:

1. Department of Pharmaceutical Organic Chemistry, College of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

2. Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA

3. Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt, 11835, Cairo, Egypt

5. Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

6. Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA

7. University of Science and Technology, Nanoscience Program, Zewail City of Science and Technology, October Gardens, 6th of October, Giza 12578, Egypt

Abstract

The structure–activity relationship of a new tert-butylphenylthiazole series, with a pyrimidine linker, was investigated.

Funder

Science and Technology Development Fund

Publisher

Royal Society of Chemistry (RSC)

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